Reversal Strategies for Intracranial Hemorrhages in Patients Taking Oral Factor Xa Inhibitors
نویسندگان
چکیده
منابع مشابه
Oral direct factor Xa inhibitors.
Vitamin K antagonists, such as warfarin, have been the mainstay of oral anticoagulation for many decades. Although effective, warfarin has numerous limitations, including a variable dose requirement from patient to patient because of differences in dietary vitamin K intake, common genetic polymorphisms, and multiple drug interactions that affect its pharmacodynamics and metabolism. Consequently...
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The new oral anticoagulants dabigatran, rivaroxaban and apixaban have advantages over warfarin which include no need for laboratory monitoring, less drug-drug interactions and less food-drug interactions. However, there is no established antidote for patients who are bleeding or require emergent surgery and there is a paucity of evidence to guide the clinical care during these situations. Membe...
متن کاملOral direct thrombin inhibitors or oral factor Xa inhibitors for the treatment of deep vein thrombosis.
BACKGROUND Deep vein thrombosis (DVT) is a condition in which a clot forms in the deep veins, most commonly of the leg. It occurs in approximately 1 in 1,000 people. If left untreated, the clot can travel up to the lungs and cause a potentially life-threatening pulmonary embolism (PE). Previously, a DVT was treated with the anticoagulants heparin and vitamin K antagonists. However, two forms of...
متن کاملcontinuing education Oral , Direct Factor Xa Inhibitors and Thromboembolic Disorders
pon successful completion of this article, the pharmacist should be able to: 1. List the advantages and disadvantages of currently available anticoagulants. 2. Discuss the role of Factor Xa (FXa) in the coagulation cascade and the rationale for selected FXa inhibition as a target for drug development. 3. Discuss the pharmacology of apixaban and rivaroxaban: mechanism of action, pharmacokinetics...
متن کاملPharmacodynamics and Pharmacokinetics of oral factor Xa inhibitors
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ژورنال
عنوان ژورنال: Hospital Pharmacy
سال: 2015
ISSN: 0018-5787,1945-1253
DOI: 10.1310/hpj5007-569